Biospecimen

Attribute: Biospecimen Type Category

Valid Value	Description	Ontology
Ascites	A biospecimen of ascitic fluid.	NCIT:C159203
Blood	A small volume of blood removed for testing or storage.	NCIT:C17610
Bone Marrow	A biological sample containing components collected from bone marrow of an experimental subject.	NCIT:C164009
Cells	A biospecimen comprised of purified or partially-purified cells.	NCIT:C192998
Body Fluid or Substance	Material produced by living organisms; a necessary constituent of, or product of, an organismal process.	NCIT:C13236
Cell Line	A permanently established cell culture that will proliferate indefinitely given appropriate fresh medium and space.	NCIT:C16403
Central Nervous System	The part of the nervous system that consists of the brain, spinal cord, and meninges.	NCIT:C12438
Mouth Rinse	A sample consisting of biological material from the buccal cavity, collected by introducing a solution into the mouth, swishing, and collecting the rinse.	NCIT:C198712
Saliva	The watery fluid in the mouth produced by the salivary glands that moistens food to aid digestion and helps protect the mouth against infection.	NCIT:C13275
Skin	An organ that constitutes the external surface of the body, consisting of the epidermis, dermis, and skin appendages.	NCIT:C12470
Sputum	A respiratory biospecimen obtained via expectoration.	NCIT:C189124
Stool	Portion of semisolid bodily waste discharged through the anus.	UBERON:0001988
Tissue	A piece of tissue removed from an organism for examination, analysis, or propagation.	NCIT:C19697
Urine	A biospecimen obtained from urine.	NCIT:C189126
RNA	A biospecimen consisting of isolated or enriched ribonucleic acid (RNA).	NCIT:C198568
DNA	A biospecimen consisting of extracted deoxyribonucleic acid (DNA).	NCIT:C449
Xenograft	A biospecimen derived from the culturing of a derived cell line in a non-human organism.	NCIT:C156443
Not Reported	Not provided or available.	NCIT:C43234
Unknown	Not known, observed, recorded, or reported as unknown by the data contributor.	NCIT:C17998

Attribute: Biospecimen Type

Valid Value	Description	Ontology
Additional - New Primary	A biospecimen collected from a new primary malignancy that arose in a patient in addition to a previously diagnosed primary tumor.	NCIT:C156441
Additional Metastatic	A biospecimen derived from an additional metastatic tumor site, collected separately from the first-sampled metastatic lesion.	NCIT:C156440
Analyte	A substance or chemical constituent extracted or purified from a biospecimen that serves as the target of an analytical procedure, such as a nucleic acid or protein preparation.	NCIT:C128639
Benign Neoplasms	A neoplasm that lacks the morphologic features of malignancy, such as severe cytologic atypia or tumor cell necrosis, and remains confined to its site of origin without metastasizing.	MONDO:0005165
Blood Buffy Coat	The fraction of an anticoagulated blood sample that contains most of the white blood cells and platelets following density gradient centrifugation of whole blood.	BTO:0006181
Blood Clot	A semisolid gelatinous mass of coagulated blood consisting of red blood cells, white blood cells, and platelets entrapped in a fibrin network.	UBERON:0010210
Blood Derived Cancer - Bone Marrow	A bone marrow specimen collected from a subject that has been diagnosed with a hematologic (blood-derived) malignancy.	NCIT:C164015
Blood Derived Cancer - Bone Marrow; Post-treatment	A bone marrow specimen collected from a subject with a hematologic malignancy after the subject has received treatment.	NCIT:C164017
Blood Derived Cancer - Peripheral Blood	A peripheral whole blood specimen collected from a subject that has been diagnosed with a hematologic (blood-derived) malignancy.	NCIT:C164030
Blood Derived Cancer - Peripheral Blood; Post-treatment	A peripheral whole blood specimen collected from a subject with a hematologic malignancy after the subject has received treatment.	NCIT:C164031
Blood Derived Liquid Biopsy	A blood-based liquid biopsy specimen used to sample circulating tumor cells, cell-free nucleic acids, or other tumor-derived material without a solid tissue biopsy.	NCIT:C135727
Blood Derived Normal	A peripheral blood specimen collected from a subject that is used as a source of germline (non-tumor) DNA or as a matched normal control for genomic comparisons.	NCIT:C17610
Body Fluid	A liquid substance derived from the body, such as blood, urine, cerebrospinal fluid, or pleural effusion, that is collected as a biospecimen.	EMAPA:37441
Bone Marrow Normal	A bone marrow specimen collected from a subject that does not contain malignant cells and is used as a normal reference sample.	NCIT:C164009
Buccal Cell Normal	A sample of normal (non-tumor) cells collected by scraping or swabbing the inside of a subject's cheek, commonly used as a source of germline DNA.	NCIT:C172264
Cell	The smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm containing a nucleus or nucleoid.	NCIT:C12508
Cell Line Derived Xenograft Tissue	A biospecimen derived from tissue that developed after a laboratory cell line was implanted and grown in a non-human host organism.	NCIT:C156443
Cell Lines	A permanently established cell culture that will proliferate indefinitely given appropriate fresh medium and growth space.	NCIT:C16403
Control Analyte	A biospecimen or analyte that is used as a comparator or reference against an experimental sample.	NCIT:C156442
DNA	A long, linear, double-stranded polymer of nucleotides attached to a deoxyribose backbone that carries an organism's genetic information; used here to denote a specimen consisting of extracted DNA.	NCIT:C449
EBV Immortalized Normal	A biospecimen consisting of normal lymphocytes that have been infected in vitro with Epstein-Barr virus (EBV) and cultured to establish an indefinitely proliferating cell line.	NCIT:C163993
Expanded Next Generation Cancer Model	A next generation cancer model that has been expanded using tissue culture or other propagation methods.	NCIT:C184757
FFPE Recurrent	A formalin-fixed, paraffin-embedded tissue sample derived from tissue isolated from a subject with recurrent disease.	NCIT:C172267
FFPE Scrolls	A formalin-fixed, paraffin-embedded tissue sample that has been cut on a microtome into a thin section that rolls up on itself, forming a scroll.	NCIT:C172268
Fibroblasts from Bone Marrow Normal	Fibroblast cells isolated from a normal (non-malignant) bone marrow specimen.	NCIT:C12482
GenomePlex (Rubicon) Amplified DNA	A DNA specimen that has been amplified using the GenomePlex (Rubicon Genomics) whole genome amplification method.	NCIT:C198569
Granulocytes	A type of leukocyte with a multilobed nucleus and cytoplasmic granules, subdivided into eosinophils, basophils, and neutrophils based on the staining properties of their granules.	NCIT:C12530
Human Tumor Original Cells	A sample comprised of cells that were isolated from a human tumor and have not been cultured or expanded.	NCIT:C172293
In Situ Neoplasms	Neoplasms confined to the site of origin without invasion beyond the basement membrane or into surrounding tissue, such as carcinoma in situ.	NCIT:C36118
Lymphoid Normal	A specimen of normal (non-malignant) lymphoid tissue or cells used as a reference or control sample.	NCIT:C13049
Metastatic	A term referring to the clinical or pathologic observation of a tumor extension from its original site of growth to another anatomic site.	NCIT:C14174
Mixed Adherent Suspension	A sample comprised of a mixture of cells or clumps of cells, which may have been isolated from normal or tumor tissue, that are maintained together in a suspension culture.	NCIT:C174118
Mononuclear Cells from Bone Marrow Normal	A biological sample containing mononuclear cells isolated from a normal (non-malignant) bone marrow specimen.	NCIT:C164011
Neoplasms of Uncertain and Unknown Behavior	Neoplasms that, on morphologic grounds, cannot be classified with certainty as benign or malignant.	NCIT:C65157
Next Generation Cancer Model	An approach to cancer modeling that utilizes clinical data as well as the genomic and transcriptomic profiles of the parent tumor, metastases, if present, and case-matched normal tissues from individual patients.	NCIT:C172295
Next Generation Cancer Model Expanded Under Non-conforming Conditions	A next generation cancer model that has been expanded using unconventional or non-standard culturing methods.	NCIT:C184781
Not Allowed To Collect	An indicator that specifies that a biospecimen collection event was not permitted.	NCIT:C141478
Pleural Effusion	Increased amounts of fluid within the pleural cavity, usually caused by lung infections, congestive heart failure, pleural or lung tumors, connective tissue disorders, or trauma.	NCIT:C3331
Post neo-adjuvant therapy	A biospecimen collected from a subject after treatment with a neoadjuvant therapeutic agent.	NCIT:C156444
Primary Blood Derived Cancer - Bone Marrow	A bone marrow specimen collected from a subject at the time of initial diagnosis of a hematologic (blood-derived) malignancy, prior to treatment.	NCIT:C164015
Primary Blood Derived Cancer - Peripheral Blood	A peripheral whole blood specimen collected from a subject at the time of initial diagnosis of a hematologic malignancy, prior to treatment.	NCIT:C164030
Primary Tumor	A tumor specimen collected from the anatomic site where the cancer originated, as opposed to a metastatic or recurrent site.	NCIT:C8509
Primary Xenograft Tissue	Tissue derived from a patient's tumor that has been directly implanted and grown in a non-human host organism without prior in vitro culturing.	NCIT:C122936
Recurrent Blood Derived Cancer - Bone Marrow	A bone marrow specimen collected from a subject at the time of relapse or recurrence of a hematologic malignancy.	NCIT:C164017
Recurrent Blood Derived Cancer - Peripheral Blood	A peripheral whole blood specimen collected from a subject at the time of relapse or recurrence of a hematologic malignancy.	NCIT:C164031
Recurrent Tumor	A tumor specimen collected after the reemergence of cancer at the original or a related site following a period of remission.	NCIT:C4798
Repli-G (Qiagen) DNA	A genomic DNA specimen that has been amplified from a limited-quantity sample using the REPLI-g (Qiagen) whole genome amplification technology.	NCIT:C156437
Repli-G X (Qiagen) DNA	A genomic DNA specimen amplified from an ultra-low-input sample using the REPLI-g X (Qiagen) whole genome amplification kit, designed for single-cell or trace-quantity starting material.	NCIT:C156439
RNA	A biospecimen created to contain an isolated or enriched ribonucleic acid (RNA) sample.	NCIT:C198568
Saliva	The watery fluid in the mouth produced by the salivary glands that moistens food to aid digestion and helps protect the mouth against infection.	NCIT:C13275
Slides	A biospecimen consisting of a tissue section or cell preparation mounted on a glass slide for microscopic examination.	NCIT:C62755
Solid Tissue Normal	A specimen of morphologically normal solid tissue collected from a subject, typically used as a matched normal control for a tumor specimen.	NCIT:C164014
Tissue	An anatomical structure consisting of similarly specialized cells and intercellular matrix, aggregated according to genetically determined spatial relationships, that performs a specific function.	NCIT:C12801
Total RNA	A biological sample comprised of all of the RNA collected from an experimental subject.	NCIT:C163995
Tumor	An abnormal mass of tissue that results from excessive cell division; used broadly to denote a neoplasm, which may be benign or malignant.	NCIT:C3262
Tumor Adjacent Normal - Post Neo-adjuvant Therapy	A specimen of morphologically normal tissue collected from the area immediately surrounding a tumor, obtained from a subject after treatment with a neoadjuvant therapeutic.	NCIT:C164033
Whole Animal	Referring to the entire body of an experimental animal; used when a biospecimen consists of or is derived from an entire organism.	NCIT:C77665
Whole Blood	Blood that has not been separated into its various components, other than the addition of an anticoagulant.	NCIT:C41067
Xenograft Tissue	Tissue derived from human or animal cells or tumor material that has been transplanted into and grown within a different (non-human) host organism.	NCIT:C122936
Unknown	Not known, observed, recorded; or reported as unknown by the data contributor.	NCIT:C17998
Not Reported	Not provided or available.	NCIT:C43234

Attribute: Biospecimen Composition

Valid Value	Description	Ontology
Metastatic	A tumor that has spread from its original site of growth to another anatomic site.	NCIT:C3261
Not Applicable	Determination of a value is not relevant in the current context.	NCIT:C48660
Not Reported	An indication that the required information was not provided.	NCIT:C43234
Premalignant	A pathological process that precedes and often leads to the development of cancer.	NCIT:C36032
Primary	A tumor at the original site at which it arose.	NCIT:C8509
Prior Primary	Recurrent Disease, Primary Site	NCIT:C55072
Progression	Progressive Disease	NCIT:C35571
Recurrent	The return of a disease after a period of remission.	NCIT:C38155
Synchronous Primary	Malignant Neoplasm of Multiple Primary Sites	NCIT:C35427
Unknown	Not known, observed, recorded, or reported as unknown by the data contributor.	NCIT:C17998
Xenograft	A transplantation of cancer cells derived from an established cancer cell line into an immunodeficient mouse.	NCIT:C156443

Attribute: Biospecimen Preservation Method

Valid Value	Description	Ontology
Cryopreserved	Preservation of cells, tissues, organs, or embryos by storage at low temperatures.	NCIT:C16475
Cytospin Slide	A slide prepared by centrifuging a cell suspension to concentrate cells onto the slide surface.	NCIT:C115350
Fixation	The chemical preservation of a substance to maintain structural and/or molecular features of that substance as they exist in the living entity.	NCIT:C25219
Fresh	Tissue which has not been exposed to a fixative solution.	NCIT:C84517
Fresh Dissociated	A tissue preparation process that takes fresh tissue and dissociates it into single cell suspensions.	NCIT:C185404
Fresh Dissociated and Single Cell Sorted	A tissue preparation process that separates fresh dissociated tissue cells into cell populations by single cell sorting.	NCIT:C185405
Fresh Dissociated and Single Cell Sorted into Plates	A tissue preparation process that takes dissociated, sorted cells and distributes them into cell propagation plates.	NCIT:C185406
Frozen	A tissue sample that has been frozen prior to analysis.	NCIT:C158417
Not Applicable	Determination of a value is not relevant in the current context.	NCIT:C48660
Not Reported	An indication that the required information was not provided.	NCIT:C43234
Refrigerated	A specimen that has been kept or preserved at a low temperature in a refrigerator.	NCIT:C70718
Refrigerated Vacuum Chamber	A device designed to maintain a vacuum at a below-ambient temperature.	NCIT:C185340
Snap Frozen	To freeze rapidly so as to preserve structure and prevent ice crystal formation.	NCIT:C63521
Unknown	Not known, observed, recorded; or reported as unknown by the data contributor.	NCIT:C17998

Attribute: Biospecimen Tumor Morphology

Valid Value	Description	Ontology
8000/0	No description provided	Not available
8000/1	No description provided	Not available
8000/3	No description provided	Not available
8000/6	No description provided	Not available
8000/9	No description provided	Not available
8001/0	No description provided	Not available
8001/1	No description provided	Not available
8001/3	No description provided	Not available
8002/3	No description provided	Not available
8003/3	No description provided	Not available
8004/3	No description provided	Not available
8005/0	No description provided	Not available
8005/3	No description provided	Not available
8010/0	No description provided	Not available
8010/2	No description provided	Not available
8010/3	No description provided	Not available
8010/6	No description provided	Not available
8010/9	No description provided	Not available
8011/0	No description provided	Not available
8011/3	No description provided	Not available
8012/3	No description provided	Not available
8013/3	No description provided	Not available
8014/3	No description provided	Not available
8015/3	No description provided	Not available
8020/3	No description provided	Not available
8020/6	No description provided	Not available
8021/3	No description provided	Not available
8022/3	No description provided	Not available
8023/3	No description provided	Not available
8030/3	No description provided	Not available
8031/3	No description provided	Not available
8032/3	No description provided	Not available
8033/3	No description provided	Not available
8034/3	No description provided	Not available
8035/3	No description provided	Not available
8040/0	No description provided	Not available
8040/1	No description provided	Not available
8040/3	No description provided	Not available
8041/3	No description provided	Not available
8041/34	No description provided	Not available
8041/6	No description provided	Not available
8042/3	No description provided	Not available
8043/3	No description provided	Not available
8044/3	No description provided	Not available
8045/3	No description provided	Not available
8046/3	No description provided	Not available
8046/6	No description provided	Not available
8050/0	No description provided	Not available
8050/2	No description provided	Not available
8050/3	No description provided	Not available
8051/0	No description provided	Not available
8051/3	No description provided	Not available
8052/0	No description provided	Not available
8052/2	No description provided	Not available
8052/3	No description provided	Not available
8053/0	No description provided	Not available
8060/0	No description provided	Not available
8070/2	No description provided	Not available
8070/3	No description provided	Not available
8070/33	No description provided	Not available
8070/6	No description provided	Not available
8071/2	No description provided	Not available
8071/3	No description provided	Not available
8072/3	No description provided	Not available
8073/3	No description provided	Not available
8074/3	No description provided	Not available
8075/3	No description provided	Not available
8076/2	No description provided	Not available
8076/3	No description provided	Not available
8077/0	No description provided	Not available
8077/2	No description provided	Not available
8078/3	No description provided	Not available
8080/2	No description provided	Not available
8081/2	No description provided	Not available
8082/3	No description provided	Not available
8083/3	No description provided	Not available
8084/3	No description provided	Not available
8085/3	No description provided	Not available
8086/3	No description provided	Not available
8090/1	No description provided	Not available
8090/3	No description provided	Not available
8091/3	No description provided	Not available
8092/3	No description provided	Not available
8093/3	No description provided	Not available
8094/3	No description provided	Not available
8095/3	No description provided	Not available
8096/0	No description provided	Not available
8097/3	No description provided	Not available
8098/3	No description provided	Not available
8100/0	No description provided	Not available
8101/0	No description provided	Not available
8102/0	No description provided	Not available
8102/3	No description provided	Not available
8103/0	No description provided	Not available
8110/0	No description provided	Not available
8110/3	No description provided	Not available
8120/0	No description provided	Not available
8120/1	No description provided	Not available
8120/2	No description provided	Not available
8120/3	No description provided	Not available
8121/0	No description provided	Not available
8121/1	No description provided	Not available
8121/3	No description provided	Not available
8122/3	No description provided	Not available
8123/3	No description provided	Not available
8124/3	No description provided	Not available
8130/1	No description provided	Not available
8130/2	No description provided	Not available
8130/3	No description provided	Not available
8131/3	No description provided	Not available
8140/0	No description provided	Not available
8140/1	No description provided	Not available
8140/2	No description provided	Not available
8140/3	No description provided	Not available
8140/33	No description provided	Not available
8140/6	No description provided	Not available
8141/3	No description provided	Not available
8142/3	No description provided	Not available
8143/3	No description provided	Not available
8144/3	No description provided	Not available
8145/3	No description provided	Not available
8146/0	No description provided	Not available
8147/0	No description provided	Not available
8147/3	No description provided	Not available
8148/0	No description provided	Not available
8148/2	No description provided	Not available
8149/0	No description provided	Not available
8150/0	No description provided	Not available
8150/1	No description provided	Not available
8150/3	No description provided	Not available
8151/0	No description provided	Not available
8151/3	No description provided	Not available
8152/1	No description provided	Not available
8152/3	No description provided	Not available
8153/1	No description provided	Not available
8153/3	No description provided	Not available
8154/3	No description provided	Not available
8155/1	No description provided	Not available
8155/3	No description provided	Not available
8156/1	No description provided	Not available
8156/3	No description provided	Not available
8158/1	No description provided	Not available
8160/0	No description provided	Not available
8160/3	No description provided	Not available
8161/0	No description provided	Not available
8161/3	No description provided	Not available
8162/3	No description provided	Not available
8163/0	No description provided	Not available
8163/2	No description provided	Not available
8163/3	No description provided	Not available
8170/0	No description provided	Not available
8170/3	No description provided	Not available
8171/3	No description provided	Not available
8172/3	No description provided	Not available
8173/3	No description provided	Not available
8174/3	No description provided	Not available
8175/3	No description provided	Not available
8180/3	No description provided	Not available
8190/0	No description provided	Not available
8190/3	No description provided	Not available
8191/0	No description provided	Not available
8200/0	No description provided	Not available
8200/3	No description provided	Not available
8201/2	No description provided	Not available
8201/3	No description provided	Not available
8202/0	No description provided	Not available
8204/0	No description provided	Not available
8210/0	No description provided	Not available
8210/2	No description provided	Not available
8210/3	No description provided	Not available
8211/0	No description provided	Not available
8211/3	No description provided	Not available
8212/0	No description provided	Not available
8213/0	No description provided	Not available
8213/3	No description provided	Not available
8214/3	No description provided	Not available
8215/3	No description provided	Not available
8220/0	No description provided	Not available
8220/3	No description provided	Not available
8221/0	No description provided	Not available
8221/3	No description provided	Not available
8230/2	No description provided	Not available
8230/3	No description provided	Not available
8231/3	No description provided	Not available
8240/1	No description provided	Not available
8240/3	No description provided	Not available
8240/6	No description provided	Not available
8241/3	No description provided	Not available
8242/1	No description provided	Not available
8242/3	No description provided	Not available
8243/3	No description provided	Not available
8244/3	No description provided	Not available
8245/1	No description provided	Not available
8245/3	No description provided	Not available
8246/3	No description provided	Not available
8246/6	No description provided	Not available
8247/3	No description provided	Not available
8248/1	No description provided	Not available
8249/3	No description provided	Not available
8249/6	No description provided	Not available
8250/1	No description provided	Not available
8250/2	No description provided	Not available
8250/3	No description provided	Not available
8251/0	No description provided	Not available
8251/3	No description provided	Not available
8252/3	No description provided	Not available
8253/3	No description provided	Not available
8254/3	No description provided	Not available
8255/3	No description provided	Not available
8256/3	No description provided	Not available
8257/3	No description provided	Not available
8260/0	No description provided	Not available
8260/3	No description provided	Not available
8261/0	No description provided	Not available
8261/2	No description provided	Not available
8261/3	No description provided	Not available
8262/3	No description provided	Not available
8263/0	No description provided	Not available
8263/2	No description provided	Not available
8263/3	No description provided	Not available
8264/0	No description provided	Not available
8265/3	No description provided	Not available
8270/0	No description provided	Not available
8270/3	No description provided	Not available
8271/0	No description provided	Not available
8272/0	No description provided	Not available
8272/3	No description provided	Not available
8280/0	No description provided	Not available
8280/3	No description provided	Not available
8281/0	No description provided	Not available
8281/3	No description provided	Not available
8290/0	No description provided	Not available
8290/3	No description provided	Not available
8300/0	No description provided	Not available
8300/3	No description provided	Not available
8310/0	No description provided	Not available
8310/3	No description provided	Not available
8310/6	No description provided	Not available
8311/1	No description provided	Not available
8311/3	No description provided	Not available
8311/6	No description provided	Not available
8312/3	No description provided	Not available
8313/0	No description provided	Not available
8313/1	No description provided	Not available
8313/3	No description provided	Not available
8314/3	No description provided	Not available
8315/3	No description provided	Not available
8316/3	No description provided	Not available
8317/3	No description provided	Not available
8318/3	No description provided	Not available
8319/3	No description provided	Not available
8320/3	No description provided	Not available
8321/0	No description provided	Not available
8322/0	No description provided	Not available
8322/3	No description provided	Not available
8323/0	No description provided	Not available
8323/3	No description provided	Not available
8324/0	No description provided	Not available
8325/0	No description provided	Not available
8330/0	No description provided	Not available
8330/1	No description provided	Not available
8330/3	No description provided	Not available
8331/3	No description provided	Not available
8332/3	No description provided	Not available
8333/0	No description provided	Not available
8333/3	No description provided	Not available
8334/0	No description provided	Not available
8335/3	No description provided	Not available
8336/0	No description provided	Not available
8337/3	No description provided	Not available
8339/3	No description provided	Not available
8340/3	No description provided	Not available
8341/3	No description provided	Not available
8342/3	No description provided	Not available
8343/2	No description provided	Not available
8343/3	No description provided	Not available
8344/3	No description provided	Not available
8345/3	No description provided	Not available
8346/3	No description provided	Not available
8347/3	No description provided	Not available
8350/3	No description provided	Not available
8360/1	No description provided	Not available
8361/0	No description provided	Not available
8370/0	No description provided	Not available
8370/1	No description provided	Not available
8370/3	No description provided	Not available
8371/0	No description provided	Not available
8372/0	No description provided	Not available
8373/0	No description provided	Not available
8374/0	No description provided	Not available
8375/0	No description provided	Not available
8380/0	No description provided	Not available
8380/1	No description provided	Not available
8380/2	No description provided	Not available
8380/3	No description provided	Not available
8380/6	No description provided	Not available
8381/0	No description provided	Not available
8381/1	No description provided	Not available
8381/3	No description provided	Not available
8382/3	No description provided	Not available
8383/3	No description provided	Not available
8384/3	No description provided	Not available
8390/0	No description provided	Not available
8390/3	No description provided	Not available
8391/0	No description provided	Not available
8392/0	No description provided	Not available
8400/0	No description provided	Not available
8400/1	No description provided	Not available
8400/3	No description provided	Not available
8401/0	No description provided	Not available
8401/3	No description provided	Not available
8402/0	No description provided	Not available
8402/3	No description provided	Not available
8403/0	No description provided	Not available
8403/3	No description provided	Not available
8404/0	No description provided	Not available
8405/0	No description provided	Not available
8406/0	No description provided	Not available
8407/0	No description provided	Not available
8407/3	No description provided	Not available
8408/0	No description provided	Not available
8408/1	No description provided	Not available
8408/3	No description provided	Not available
8409/0	No description provided	Not available
8409/3	No description provided	Not available
8410/0	No description provided	Not available
8410/3	No description provided	Not available
8413/3	No description provided	Not available
8420/0	No description provided	Not available
8420/3	No description provided	Not available
8430/1	No description provided	Not available
8430/3	No description provided	Not available
8440/0	No description provided	Not available
8440/3	No description provided	Not available
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9531/0	No description provided	Not available
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9533/0	No description provided	Not available
9534/0	No description provided	Not available
9535/0	No description provided	Not available
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9570/0	No description provided	Not available
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9580/0	No description provided	Not available
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9582/0	No description provided	Not available
9590/3	No description provided	Not available
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9597/3	No description provided	Not available
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9667/3	No description provided	Not available
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9684/3	No description provided	Not available
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9689/3	No description provided	Not available
9690/3	No description provided	Not available
9691/3	No description provided	Not available
9695/3	No description provided	Not available
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9699/3	No description provided	Not available
9700/3	No description provided	Not available
9701/3	No description provided	Not available
9702/3	No description provided	Not available
9705/3	No description provided	Not available
9708/3	No description provided	Not available
9709/3	No description provided	Not available
9712/3	No description provided	Not available
9714/3	No description provided	Not available
9716/3	No description provided	Not available
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9805/3	No description provided	Not available
9806/3	No description provided	Not available
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9808/3	No description provided	Not available
9809/3	No description provided	Not available
9811/3	No description provided	Not available
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9987/3	No description provided	Not available
9989/3	No description provided	Not available
9991/3	No description provided	Not available
9992/3	No description provided	Not available
Unknown	No description provided	Not available
Not Reported	No description provided	Not available

Attribute: Biospecimen Preservation Medium

Valid Value	Description	Ontology
Desiccant	A material that absorbs moisture from its surrounding environment.	NCIT:C219695
EDTA	Edetic Acid	NCIT:C61742
FFPE	Formalin-Fixed Paraffin-Embedded	NCIT:C143028
Formalin Fixed - Buffered	Buffered Formalin Fixation	NCIT:C185403
Formalin Fixed - Unbuffered	Unbuffered Formalin Fixation	NCIT:C185402
Formalin Fixed Tissue	Formalin-Fixed Tissue	NCIT:C200862
Glutaraldehyde	A water-soluble oily liquid, C5H8O2, containing two aldehyde groups, used as a disinfectant and as a fixative for biological tissues.	NCIT:C80930
RNALater	Trade name for an aqueous, non-toxic tissue storage reagent that rapidly permeates tissues to stabilize and protect cellular RNA.	NCIT:C63348
TRIzol	Phenol and Guanidine Isothiocyanate Solution	NCIT:C213680
OCT	Optimal Cutting Temperature Compound	NCIT:C63523
Paraffin Block	Paraffin Embedded Tissue	NCIT:C19597
Isopentane	An organic, branched-chain alkane with five carbon atoms.	NCIT:C63387
Not Applicable	Not applicable	NCIT:C48660
Not Reported	Not provided or available.	NCIT:C43234
Unknown	Not known, observed, recorded; or reported as unknown by the data contributor.	NCIT:C17998
Liquid Nitrogen Vapor	The gaseous state of liquid nitrogen with a temperature of -167 degrees Celsius.	NCIT:C174159
Liquid Nitrogen	Nitrogen in a liquid state, having been super-cooled to -196 degrees Celsius.	NCIT:C68796

Attribute: Biospecimen Embedding Medium

Valid Value	Description	Ontology
Paraffin wax	A common name for a group of high molecular weight alkane hydrocarbons; a white, odorless, tasteless, waxy solid widely used as an embedding medium for tissue processing in histology.	NCIT:C727
Carbowax	A trade name for polyethylene glycol (PEG), a water-soluble, wax-like polymer historically used as an embedding medium for light microscopy that allows sections to be stained without prior dewaxing.	NCIT:C762
Methacrylate	A methyl ester of methacrylic acid; a reactive resin used as cement in dentistry, orthopaedic surgery, and ophthalmology, and as a hard plastic embedding medium for electron microscopy.	NCIT:C47615
Epoxy Resin (Araldite)	A class of thermosetting polymer resins (e.g., Araldite) formed by curing epoxide monomers with a hardener; used as a hard, transparent embedding medium for ultrathin sectioning in transmission electron microscopy.	MESH:D004853
Agar embedding	Use of agar, a gelatinous polysaccharide extracted from red algae, as a supporting medium to consolidate small, fragmented, or friable tissue specimens prior to histological processing and sectioning.	MESH:D000362
Celloidin media	A purified nitrocellulose (collodion) solution in ether and alcohol; historically used as an embedding medium for sectioning large, hard, or heterogeneous specimens (e.g., whole organs, decalcified bone) that are poorly suited to paraffin embedding.	MESH:D003101
Gelatin	A translucent, colorless, water-soluble protein derived from collagen; used as an embedding medium for cryosectioning and to orient or support small, friable tissue specimens.	NCIT:C65802
Other	Different than the one(s) previously specified or mentioned.	NCIT:C17649
None	No person or thing, nobody, not any.	NCIT:C41132
Unknown	Not known, observed, recorded, or reported as unknown by the data contributor.	NCIT:C17998

Attribute: Biospecimen Pathology

Valid Value	Description	Ontology
Metastatic Neoplasm	A malignant tumor that has spread from its original site of growth to another anatomic location.	NCIT:C3261
Not Applicable	Determination of a value is not relevant in the current context.	NCIT:C48660
Not Otherwise Specified	Not characterized in any other way.	NCIT:C19594
Not Reported	Not provided or available.	NCIT:C43234
Premalignant Neoplasm	A lesion or cellular condition with the potential to develop into cancer.	NCIT:C36032
Primary Neoplasm	A neoplasm at the original site of growth.	NCIT:C8509
Recurrent Neoplasm	A lesion that has reappeared at the original site of a neoplasm after a period of remission.	NCIT:C4798
Unknown	Not known, observed, recorded, or reported as unknown by the data contributor.	NCIT:C17998
Xenograft	A biospecimen derived from the culturing of a derived cell line in a non-human organism.	NCIT:C156443

Attribute: Biospecimen Tumor Status

Valid Value	Description	Ontology
Tumor	Tissue sample that contains an abnormal cellular infiltrate forming a solid mass.	NCIT:C18009
Normal	Tissue sample with cellular composition and architectural patterns expected for the particular anatomic site in which it belongs. There is no evidence of abnormal cellular infiltrates or tumor mass formation.	NCIT:C162623
Not Reported	An indication that the required information was not provided.	NCIT:C43234
Peritumoral	Located in tissues surrounding a tumor.	NCIT:C119010
Unknown	Not known, observed, recorded, or reported as unknown by the data contributor.	NCIT:C17998

Attribute: Biospecimen Incidence Type

Valid Value	Description	Ontology
Primary	Occurring first in time or sequence; original; of greatest rank or importance or value.	NCIT:C25251
Progression	A clinical, pathologic, and/or molecular finding indicating that the course of a disease is worsening in terms of extent or severity.	NCIT:C35571
Recurrence	The return of a disease after a period of remission.	NCIT:C38155
Metastasis	The spread of a neoplasm from the original site of growth to another site.	NCIT:C19151
Remission	A state in which the signs and symptoms of a disease are reduced or absent.	NCIT:C18246
No Disease	Diagnostic tests fail to detect presence of disease.	NCIT:C40413

Attribute: Biospecimen Acquisition Method

Valid Value	Description	Ontology
Aspiration	Procedure using suction, usually with a thin needle and syringe, to remove bodily fluid or tissue.	NCIT:C15631
Blood Draw	A small volume of blood removed for testing or storage.	NCIT:C17610
Bone Marrow Aspiration	Aspiration of immature hematopoietic elements and blood from the bone marrow. It is done for the evaluation of hematopoietic disorders and for the evaluation of infectious diseases and cytogenetic studies.	NCIT:C15644
Excisional Biopsy	A surgical procedure in which an entire lesion is removed for microscopic examination.	NCIT:C15385
Incisional Biopsy	A surgical procedure in which part of a lesion is removed for microscopic examination.	NCIT:C15386
Needle Biopsy	The removal of a tissue sample using a needle, for microscopic examination.	NCIT:C15190
Not Reported	Not provided or available.	NCIT:C43234
Other	Different than the one(s) previously specified or mentioned.	NCIT:C17649
Surgical Resection	The surgical removal of all or part of an organ or tissue structure that may include a lesion.	NCIT:C158758
Tumor Resection	A surgical procedure in which cancerous tissue is surgically removed.	NCIT:C164212

Attribute: Biospecimen Stain

Valid Value	Description	Ontology
H&E	Hematoxylin-and-eosin staining: a routine staining procedure of tissue sections using two dyes to stain the nucleus and the cytoplasm/connective tissue separately.	NCIT:C23011
IHC	Immunohistochemical staining that visualizes antigens via sequential application of a primary antibody, a secondary antibody, and a chromogenic enzyme complex.	NCIT:C23020
In situ hybridization	Use of a DNA or RNA probe to detect the presence of complementary sequences in chromosomes, cells, or tissues.	NCIT:C17562
mIHC	A method that enables simultaneous detection of multiple biomarkers on a single tissue section using immunohistochemistry techniques.	NCIT:C181927
Other	Different than the one(s) previously specified or mentioned.	NCIT:C17649
Wright-Giemsa	A polychromatic stain that permits differentiation of cells present in hematopoietic tissues and demonstration of certain microorganisms.	NCIT:C23041